Patent Families

 

Analysis of target molecules within a sample via hybridization chain reaction

Harry M.T. Choi and Niles A. Pierce

Patent # JP 7,884,761. June 26, 2026

Patent # EP 4,114,969. August 6, 2025​

 

Ultrasensitive molecular detection via hybridization chain reaction

Harry MT Choi, Chun Hao R. Chen, Mike C. Liu, Aneesh Acharya, and Niles A. Pierce

Patent # US 12,281,352. April 22, 2025

 

Allosteric conditional guide RNAs for cell-selective regulation of CRISPR/Cas

Lisa Hochrein, Mikhail H. Hanewich-Hollatz, Zhewei Chen, Heyun Li, Shashank Gandhi, Marianne Bronner, and Niles A. Pierce

Patent # US 12,385,040. August 12, 2025

Patent # US 11,873,485. January 16, 2024

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Fractional initiator hybridization chain reaction

Niles A. Pierce and Harry M.T. Choi

Patent # US 12,435,359. October 7, 2025

Patent # EP 3,943,613. April 2, 2025

Patent # AU 2,021,245,196. March 27, 2025

Patent # IL 290,679. February 9, 2023

Patent # HK 40008988. July 8, 2022

Patent # IL 264,152. June 2, 2022

Patent # EP 3,481,843. January 26, 2022

Patent # US 11,214,825. January 4, 2022

Patent # AU 2,017,291,727. October 21, 2021

Patent # US 10,450,599. October 22, 2019

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Immunohistochemistry via hybridization chain reaction

Naeem S. Husain, Harry M.T. Choi, Long Cai, and Niles A. Pierce

Patent # IL 264,831. December 2, 2022

Patent # EP 3,507,296. October 12, 2022

Patent # US 10,815,519. October 27, 2020

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Small conditional RNAs

Niles A. Pierce and Lisa Hochrein

Patent # US 9,856,472. January 2, 2018

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Biomolecular self-assembly

Peng Yin and Niles A. Pierce

Patent # US 9,834,439. December 5, 2017

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PKR activation via hybridization chain reaction

Robert Dirks and Niles A. Pierce

Patent #: US 8,962,582. February 24, 2015

Patent #: US 7,960,357. June 14, 2011

Patent #: EPO 1,931,806. October 5, 2011

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Triggered molecular geometry based bioimaging probes

Peng Yin and Niles A. Pierce

Patent #: US 8,962,241. February 24, 2015

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Triggered covalent probes for imaging and silencing genetic expression

Niles A. Pierce and Jeffrey R. Vieregg

Patent #: US 8,658,780. February 25, 2014

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A versatile nucleic acid hairpin motif for programming bimolecular self-assembly pathways

Peng Yin and Niles A. Pierce

Patent #: US 9,217,151. December 22, 2015

Patent #: EPO 2,155,770. October 16, 2013

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System and method for nucleic acid sequence design

Niles A. Pierce, Brian R. Wolfe, and Joseph Zadeh

Patent #: US 8,478,543. July 2, 2013

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Triggered RNAi

Niles A. Pierce and Peng Yin

Patent #: US 8,497,364. July 30, 2013

Patent #: US 8,318,921. November 27, 2012

Patent #: US 8,241,854. August 14, 2012

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Hybridization chain reaction amplification for in situ imaging

Niles A. Pierce, Robert Dirks, and Scott E. Fraser

Patent #: US 8,507,204. August 13, 2013

Patent #: US 8,124,751. February 28, 2012

Patent #: US 7,727,721. June 1, 2010

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Hybridization chain reaction

Robert Dirks and Niles A. Pierce

Patent #: US 8,105,778. January 31, 2012

Patent #: EPO 1730161. September 8, 2010

Patent #: US 7,632,641. December 15, 2009